Epigenetic Memory Survives DNA Replication with Aid of Histone-Recycling Protein

Scientists at the University of Copenhagen discovered that during DNA replication, fission yeast Mrc1 (CLASPIN in humans) is essential for histone inheritance, a process related to cell identity stability. Mrc1 and Mcm2 form a complex that ensures histone allocation. Disruption of histone binding in the connector domain and other histone-binding mutations impair recycling, influencing gene expression during cell division. The findings could have significant implications for future medical research.