Breast, Ovarian Cancer Risks of RAD51C Variants Assessed with Saturation Genome Editing

The RAD51C gene responsible for DNA repair can increase the risks of breast and ovarian cancer if impaired. Researchers found over 3,000 harmful genetic changes that could disrupt its function and heighten these cancer risks. Their work uncovered crucial surface areas of RAD51C required for DNA repair and indicated that genetic risk for these cancers exists on a spectrum. This understanding can aid in future risk prediction, prevention strategies, and potential therapies.