How Herpes’ DNA Polymerase Helps Virus Evade Antiviral Drugs

Viral DNA polymerase structure alterations enable resistance to antiviral drugs, according to a study by researchers at Harvard Medical School. Using cryogenic electron microscopy, the team identified how conformational changes in the herpes simplex virus’ DNA polymerase reduce the virus’s susceptibility to drugs. The results could enhance the understanding of drug resistance in other viruses and answer longstanding questions about why some viruses are more resistant than others.